Determination of 3D structures

Biomolecules are too small to observe in detail, even with the most advanced light microscopes. These may include macro and micro molecules along with natural products. These may be endogenous and exogenous in nature. Structural biologists generally use these methods to determine the structures of identical molecules in a huge quantity at a time. Scientists use these methods to study the “real states” of the biomolecules. Some of the best methods include X-ray crystallography, Cryo-Electron Microscopy and Nuclear Magnetic Resonance.

  • X-ray crystallography
  • Nuclear Magnetic Resonances
  • Cryo-Electron Microscopy
  • Powder diffractometry
  • Mass spectroscopy
  • Dual polarisation interferometry
  • Multi-angle light scattering Technique
  • Ultra-fast laser spectroscopy

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