Qiu-Xing Jiang
University of Florida, USA
Biography
Qiu-Xing Jiang is currently heading the Laboratory of Molecular Biophysics and Cell Physiology in the Department of Microbiology and Cell Science in the Institute of Food and Agricultural Sciences of University of Florida (UF), and he is serving part-time (20%) as the faculty director of Electron Microscopy at the Institute of Cross-disciplinary Biotechnology Research (ICBR) at UF. His lab is working on lipid-dependent gating effects and on a newly discovered anion conductance in ithe regulated secretory pathways. Dr. Jiang obtained his PhD in 2002 from the Department of Cellular and Molecular Physiology at Yale University School of Medicine, where he started his work in cryo-electron microscopy (cryoEM) in 1999 with Dr. Fred Sigworth. He initiated the implementation of spherically constrained reconstruction (SCR) by imaging membrane proteins in small vesicles. After a short postdoctoral training at Yale, Dr. Jiang finished his postdoctoral training in structural biology with Dr. Roderick Mackinnon in 2007 before taking an Assistant Professorship position at UT Southwestern Medical Center at Dallas, Texas. During the time at Dallas, Dr. Jiang worked on the development of chemically functionalized carbon films for cryoEM imaging, and made new discoveries on the filament-based signal amplification in the innate immune response against RNA viruses. He studied membrane-induced pore formation by human C-type Lectin and the VopQ proteins, and discovered the mechanism for lipid-dependent gating of Kv channels. He has published 24 papers in international journals. He is the recipient of the NIH EUREKA award in 2009, the AHA National Innovative Award in 2012, and the Junior Faculty travel award from GRC Molecular and Cell Biology of Lipids in 2011.
Abstract
Abstract : Structural basis for the lipid-dependent gating of a Kv channel