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Paola Picotti

ETH Zurich, Switzerland

Biography

After her PhD at the University of Padua (Italy) Paola Picotti joined the group of Ruedi Aebersold at ETH Zuerich (Switzerland), where she developed novel targeted proteomic techniques. In 2011 she was appointed assistant professor at ETH Zurich. Her group develops structural and chemoproteomics methods and uses them to study the consequences of intracellular protein aggregation. Paola Picotti’s research was awarded an ERC Starting grant, a Professorship grant from the Swiss National Science Foundation, the Latsis Prize, the Robert J. Cotter Award, the SGMS Award and the EMBO Young Investigator Award. Main contributions of the Picotti group are the development of a structural method to analyze protein conformational changes on a system-wide level, the discovery of novel allosteric interactions, the analysis of the determinants of proteome thermostability and the identification of a novel neuronal clearance mechanism for a protein involved in Parkinson’s disease.

Abstract

Abstract : Monitoring protein structural changes on a proteome-wide scale