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Charles W. Carter, Jr


Charles W. Carter, Jr

University of North Carolina, USA

Biography

Charlie Carter is an X-ray crystallographer who studies the origin, evolution, and structural biology of aminoacyl-tRNA synthetases. His research group introduced the use of Urzymes—highly conserved structural cores that retain large fractions of the transition-state stabilization free enregies of full length enzymes—as experimental models of ancestral enzymes. 

Abstract

Abstract : How Does Domain Motion Contribute to Transition-State Stabilization? Combinatorial Thermodynamic Cycle Analysis of Conformational Coupling During Tryptophan Activation