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Alfredo De Biasio

Alfredo De Biasio

Elettra-Sincrotrone Trieste, Italy


Alfredo De Biasio’s work focuses on the structure and function of DNA sliding clamps and their complexes operating in DNA replication and repair. He is particularly interested in understanding the mechanisms of sliding of the eukaryotic clamp PCNA, and how these mechanisms are modulated by modifications of the PCNA sliding surface, and the implications in DNA damage avoidance. These problems are tackled by an integrative approach that combines X-ray crystallography, NMR and MD simulations.   


Abstract : Integrative approaches to study the structure and motions of DNA sliding clamps