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Joachim Krebs

MPI for Biophysical Chemistry Göttingen, Germany

Title: Regulation of the Calcium Pump of Plasma Membranes by Calmodulin

Biography

Biography: Joachim Krebs

Abstract

Calcium is the third most abundant metal in nature and a versatile carrier of many signals within and outside the cell. Due to its peculiar coordination chemistry calcium is highly flexible as a ligand which enables it to regulate many important aspects of cellular activity. Calcium can fulfill its many different functions insite and out of the cell due to an integrated network of calcium channels, exchangers and pumps. In this presentation I will give an overview on our studies of the interaction and regulation of the plasma membrane calcium pump (PMCA) by calmodulin, and the importance of the spliced isoforms of PMCA with special emphasis on the possible regulation of expression of PMCA1a, the neuronal specific isoform of PMCA, by the thyroid hormone T3.