Sangwook Wu
1Pukyong National University, South Korea
Title: Network analysis of the conformational change of c-Src, a tyrosine kinase, by molecular dynamics simulation
Biography
Biography: Sangwook Wu
Abstract
Non-receptor tyrosine kinase c-Src plays a critical role in numerous cellular signaling pathways. Activation of c-Src
involves a change from its inactive to the active state accompanied by large-scale conformational change depending
on the phosphorylation state of two major phosphorylation sites, Tyr416 and Tyr527. A detailed mechanism for the entire
conformational transition of c-Src via phosphorylation control of Tyr416 and Tyr527 is still elusive. In this study, we investigated
the inactive to active conformational change of c-Src by targeted molecular dynamics simulation. Based on the simulation, we
proposed a dynamical scenario for the activation process of c-Src. A detailed study of the conformational transition pathway
based on network analysis suggests that Lys321 plays a key role in the c-Src activation process.