Joachim Krebs
Max Planck Institute for Biophysical Chemistry, Germany
Title: Calcium, Calmodulin and the Plasma Membrane Calcium Pump
Biography
Biography: Joachim Krebs
Abstract
Calcium is the third most abundant metal in nature and a versatile carrier of many signals within and outside the cell. Due to its peculiar coordination chemistry calcium is highly flexible as a ligand which enables it to regulate many important aspects of cellular activity. Calcium can fulfill its many different functions insite and out of the cell due to an integrated network of calcium channels, exchangers and pumps. In this presentation I will give an overview on our studies of calcium binding proteins, their interaction with protein targets resulting in specific modulations of protein-protein interactions. This will be demonstrated by the interaction of the calcium binding protein calmodulin with one of its targets, the plasma membrane calcium pump, an important regulator of calcium homeostasis of the cell.
References:
- Krebs, J. (2015) The plethora of PMCA isoforms: Alternative splicing and differential expression. Biochim. Biophys. Acta 1853: 2018-2024
- Seidel, K. et al. (2008) Structural characterization of Ca(2+)-ATPase-bound phospholamban in lipid bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy. Biochemistry 47: 4369-4376.
- Elshorst, B., Krebs, J. et al. (1999) NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+-pump. Biochemistry 38: 12320-12332.
- Carafoli, E., Krebs, J. (2016) Why Calcium? How Calcium became the best Communicator. J. Biol. Chem. 291: 20849-20857.
5.Toyoshima, C. (2009) How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane. Biochim. Biophys. Acta 1793: 941-946.