Vesa P Hytonen
University of Tampere, Finland
Title: Talin - Insights into mechanosignalling and integrin activation
Biography
Biography: Vesa P Hytonen
Abstract
Talin is cytoplasmic protein essential for cell adhesion. It connects integrin receptors for actin cytoskeleton and acts as a mechanosensor by recruiting vinculin molecules as a response to mechanical stress applied on it. We have studied talin structure and function using extensive molecular dynamics simulations, small-angle X-ray scattering, cryo-EM and biophysical methods combined with cell biology methods. These studies have revealed novel insights into role of talin in integrin activation. We have also been able to develop more detailed picture of about the role of talin rod in mechanosensing and in regulation of cell adhesion dynamics, cell migration and traction force generation.
