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Wladek Minor

Wladek Minor

University of Virginia, USA

Title: Reproducibility in Biomedical Sciences - Big Data Perspective

Biography

Biography: Wladek Minor

Abstract

Experimental reproducibility is the cornerstone of scientific research, upon which all progress rests. The veracity of scientific publications is crucial because subsequent lines of investigation rely on previous knowledge. Several recent systematic surveys of academic results published in biomedical journals reveal that a large fraction of representative sets of studies in a variety of fields cannot be reproduced in another laboratory. Big Data approach and especially NIH Big Data to Knowledge (BD2K) program is coming to the rescue.

The goal of the presented research is to provide the biomedical community with a strategy to increase the reproducibility of reported results for a wide range of experiments by building a set of “best practices”, culled by extensive data harvesting and curation combined with experimental verification of the parameters crucial for reproducibility. Experimental verification assisted by the automatic/semi-automatic harvesting of data from laboratory equipment into the already developed sophisticated laboratory information management system (LIMS) will be presented. This data in, information out paradigm will be discussed. 

References:

  1. Zheng H, Cooper DR, Porebski PJ, Shabalin IG, Handing KB, Minor W (2017) CheckMyMetal: a macromolecular metal-binding validation tool. Acta Cryst. D 73: 223-233
  2. Grabowski M, Minor W (2017) Sharing Big Data. IUCrJ 4: 3-4
  3. Rupp B, Wlodawer A, Minor W, Helliwell JR, Jaskolski M (2016) Correcting the record of structural publications requires joint effort of the community and journal editors. FEBS J. 283: 4452-4457
  4. Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016) A public database of macromolecular diffraction experiments. Acta Cryst D 72: 1181-1193
  5. Niedzialkowska E, Gasiorowska O, Handing KB, Majorek KA, Porebski PJ, Shabalin IG, Zasadzinska E, Cymborowski M, Minor W (2016) Protein purification and crystallization artifacts: The tale usually not told. Protein Science 25: 720-33